Research Focus
The main focus of our research is the identification and in-depth characterization of novel post-transcriptional regulatory elements in the biological context of stress-induced mRNA regulation in human cells. In addition to studying the biological relevance, we would like to understand the molecular details of the underlying regulatory mechanism: a) How do several regulatory elements work together? b) How are the involved effectors regulated in response to stress signals? c) What role do RNA structures play? d) Can we use these new regulatory elements as effectors in Synthetic Biology applications?
mRNA structures
The three-dimensional structure of an mRNA determines its cellular localization, stability and translation efficiency. We are working on the identification and characterization of mRNA structures that determine post-transcriptional gene regulation.
Read moremRNA stability
HnRNP DL is a paralog of the well studied hnRNP D/AUF1, which is well known for its function in mRNA decay. We are interested in the cellular functions and mRNA targets of hnRNP DL and its interconnection with hnRNP D.
Read moreHypoxia adaptation
Gene expression is regulated at all levels in response to hypoxia, ensuring cell survival at low oxygen conditions. We are particularly interested in how alternative splicing changes affect cellular adaptation.
Read moreSynthetic Biology
One goal of Synthetic Biology is the development of artificial genetic circuits. For this purpose, we create RNA devices by functionalization of endogenous RNAs with ligand-binding aptamers.
Read moreGroup Summer 2023
Additional pictures/recent activitiesWe are always looking for motivated and enthusiastic students. Please inquire for internships, practical year, bachelor and master theses.
